Personal Information

Name
Gagandeep Singh, MD

Business Address
USC Liver Transplant Program and Center for Liver Disease
1510 San Pablo Street
Suite 430
Los Angeles CA 90033-4612

Phone: (323) 442-5908
Fax: (323) 442-5721

Fellowships

Fellow: Transplant Surgery, Univ. of Iowa Hospitals & Clinics, Iowa City
Fellow: Liver Transplant Surgery, Hôpital Cochin, René Descartes Univ., Paris
Fellow: Surgical Oncology, Tata Memorial Hospital Bombay University

General Surgery Residency in the USA

Maricopa Medical Center, Phoenix, AZ, USA

Postgraduate Training in Surgery (Outside the USA) (1986-92; 1993-94)

Tata Memorial Hospital and Cancer Centre, Bombay University, India
Royal Liverpool University Hospital, Liverpool, UK

Medical School (1980-85)

Mahatma Gandhi Institute of Medical Sciences, Wardha, Nagpur University, India

• 2000
  ATLS Instructors Certification: Advanced Trauma Life Support

• 1999
  ASTS: American Society of Transplant Surgery: Certification in Transplant Surgery

• 1999
  ATLS: Advanced Trauma Life Support

• 1999, 1997
  ACLS: Advanced Cardiopulmonary Life Support BCLS: Basic Cardiopulmonary Life Support

• 1995
  ECFMG (#0-537-297-4)

• 1993
  DEA (Diplome d’Etudes Approfondies: Sciences Chirurgicale i.e. Masters in SurgicalSciences), Hôpital Cochin, René Descartes University, Paris, France

• 1989
  M.S. Degree (Master of Surgery)
  Board Certification in General Surgery, Tata Memorial Hospital and Cancer Centre
  Bombay University, India

• 1985
  M.D. Degree
  Mahatma Gandhi Institute of Medical Sciences, Nagpur University, India

• Chairman, Scientific Session on Gene therapy for Cancer at the XVI International Cancer Congress of the Union Internationale Contre de Cancer (UICC) (International Union Against Cancer), New Delhi

• Trainee Investigator Award, for excellence in scientific research
  American Federation for Clinical Research Washington DC

• "AST Trainee Travel Award"
  American Society of Transplantation, Chicago, USA

• Certificate of Achievement, for an outstanding presentation
  American Federation for Medical Research, Washington DC

• Scholarship, Centre de Recherché Appliqués A La Chimiothérapie, Paris

• "Harry W. Hale Resident of the Year Award"
  Awarded to the surgical resident who represents the ideals of an outstanding surgeon, Maricopa Medical Center, Phoenix, USA

• "Rick Weimer Medical Ethics Award"
  Awarded to a physician of admirable character who is compassionate, moral and of high integrity, Maricopa Medical Center, Phoenix, USA

• "Intern of the Year" Award
  Maricopa Medical Center, Phoenix, USA vBronze Medal for academic achievement in Medicine
  Mahatma Gandhi Institute of Medical Sciences, Wardha, India

• Research Studentship Award, Indian Council of Medical Research:
  Worked on a Field Trial for Intermittent Short Term Chemotherapy for Tuberculosis

• Bronze Medal for academic achievement in Physiology
  Mahatma Gandhi Institute of Medical Sciences, Wardha, India

1. H Mahli, A Irani, S Gagandeep, S Gupta. Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature heaptocytes. J of Cell Science. 2002; Accepted, In press

2. S Gagandeep, M Ott, P Nisen, RA DePinho, S Gupta. Overexpression of Mad transcription factor inhibits proliferation of human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals. J Gene Med. 2000; 2: 117-27.

3. S Gagandeep, R Sokhi, S Slehria, GR Gorla, J Furgiuele, RA DePinho, S Gupta. Hepatocyte transplantation improves survival in mice with liver failure induced by hepatic overexpression of Mad1 transcription factor. Molecular Therapy: the Journal of American Society of Gene Therapy. 2000; 1:358-365.

4. S Gagandeep, M Ott, R Sokhi, S Gupta. Rapid clearance of syngeneic transplanted hepatocytes following transduction with E-1-deleted adenovirus indicates early host immune responses and offers novel ways for studying viral vector, target cell and host interactions. Gene Therapy. 1999; 6: 729-736.

5. Gagandeep S, Rajvanshi P, Sokhi R, Slehria S, Palestro CJ, Bhargava KK, Gupta S. Transplanted hepatocytes engraft, survive and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis. J Pathol. 2000; 191: 78-85.

6. S Gagandeep, P Novikoff, S Gupta. Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines. Cancer Letters. 1999; 136: 109-118.

7. Gupta S, Malhi H, Gagandeep S, Novikoff PM. Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy. J Gene Med 1999; 1:386-392.

8. S Gagandeep, S Gupta. Restriction of tumoricidal gene therapy to selected hepatocellular carcinoma cells. Hepatology. 1996; 24: 1317-1319.

9. S Gagandeep, R Brew, SE Christmas, B Green, D Klatzmann, GJ Poston, AR Kinsella. Prodrug activated gene therapy: Involvement of an immunological component in the “bystander effect”. Cancer Gene Therapy. 1996; 3: 83-88.

10. S Gagandeep, B Green, GJ Poston, Z Galzie, R Sutton, AR Kinsella. Expression of basic Fibroblast Growth Factor in colorectal carcinoma. International Journal of Oncology. 1996; 8: 191-195.

11. S Gagandeep, GJ Poston, AR Kinsella. Gene Therapy in Surgical Oncology. Annals of Surgical Oncology. 1995; 2(2): 179-188.

12. M Caruso, Y Panis, S Gagandeep, D Houssin, JL Salzmann, D Klatzmann. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proceedings of the National Academy of Sciences (USA). 1993; 90: 7024-7028.

13. S Gagandeep, R Badwe , S Sharma, RK Deshpande, PB Desai. Carcinoma of the Thyroid in Children: not as malignant as in adults. Indian Journal of Surgery. 1992; 54(6) 267-273.

14. J Divatia, SC Shah, AR Fakih, S Gagandeep. Coexisting peripheral and intracranial cavernous haemangiomas. Anesthesia and Intensive Care. 1992; 20(2) 243.

15. S Gagandeep, S Sharma, RK Deshpande, PB Desai. Colonic interposition for benign and malignant long segment oesophageal strictures. Indian Journal of Surgery. 2001; in press.

16. S Gagandeep, P Novikoff, S Gupta. Stable in vivo retroviral mediated gene transfer into the liver by short term exposure to allografted producer cells. Transplantation Proceedings. 2001; in review.

17. Rajvanshi P, Bhargava KK, Afriye M, Camaya M, Gagandeep S, Vasa SRG, Palestro CJ, Gupta S. Human serum albumin microspheres approximate initial organ-specific biodistributions of transplanted hepatocytes and are effective cell surrogates for safety studies. Cell Transplantation 1998; 3:275-283.

18. M Ott, R Stockert, Q Ma, S Gagandeep, and S. Gupta. Regulation of retroviral gene transfer efficacy in the human hepatoma cell line HuH-7.MCAT-1.7 expressing the mouse cationic amino acid transporter/ ecotropic retrovirus receptor (MCAT-1). Journal of Biological Chemistry. 1998; 273(19): 11954-11961.

19. P Rajvanshi, DL Liu, M Ott, S Gagandeep, ML Schilsky, Gupta S Fractionation of rat hepatocyte subpopulations with varying metabolic potential, proliferative capacity, and retroviral gene transfer efficiency. Experimental Cell Research. 1998; 244(2): 405-419.

20. C Guha, A Sharma, S Gupta, A Alfieri, GR Gorla, S Gagandeep, RP Sokhi, , N Roy Chowdhury, KE Tanaka, B Vikram, J Roy Chowdhury. Amelioration of radiation induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Research. 1999; 59:5871-74.

21. M Ott, Q Ma, B Li, S Gagandeep, LE Rogler and S. Gupta. Regulation of hepatitis B virus expression in progenitor and differentiated cell types: evidence for negative transcriptional control in nonpermissive cells. Gene Expression. 2000; 8:175-186.

1. S Gagandeep, M Ott, R Sokhi, S Gupta. Loss of adenovirally transduced cells rather transgene extinction is rate limiting in adenoviral hepatic gene therapy. Gastroenterology. 1997; 112 (4): A1269.

2. S Gagandeep, M Ott, R Sokhi, S Gupta. Hepatocyte transplantation systems provide evidence for clearance of adenovirally transduced cells as against transgene extinction. Journal of Investigative Medicine. 1997; 45: 259A.

3. S Gagandeep, M Ott, P Nisen, R Depinho, S Gupta. Arrest of hepatic oncogenesis and growth factor expansion by the c-myc antagonist MAD transcription factor. Hepatology. 1996; 24 (4): 194A.

4. S Gagandeep, P Novikoff, M Ott, S Gupta. Paclitaxel exhibits anti-tumor activity in hepatocellular carcinoma cell lines. Hepatology. 1996; 1996; 24 (4): 348A.

5. S Gagandeep, M Ott, P Nisen, R Depinho, S Gupta. Inhibition of c-myc transactivation by mad transcription factor interrupts cycling in hepatocellular carcinoma. Journal of Investigative Medicine. 1996; 44: 281A.

6. S Gagandeep, P Novikoff, S Gupta. Retroviral hepatic gene transfer through intrasplenic transplantation of allogeneic producer cells. Journal of Investigative Medicine. 1996; 44: 327A.

7. S Gagandeep, GJ Poston, AR Kinsella. Suicide gene therapy: “The Bystander Effect” has a definite immunologic component. European Journal of Surgical Oncology. 1995; 21: 112-113.

8. S Gagandeep, R Brew, SE Christmas, B Green, D Klatzmann, GJ Poston, AR Kinsella. Involvement of an immunological component in the bystander effect. Cancer Gene Therapy. 1995; 2 (4): 332.

9. S Gagandeep, Caruso M, Panis Y, Houssin D, Salzmann JL, Klatzmann D. Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proceedings of the XVI International Cancer Congress (UICC). 1994; Pg.91 (Basic Science; OPB44-03).

10. M Ott, RJ Stockert, S Gagandeep, S. Gupta. Efficient retroviral gene transfer requires modulation of both viral receptor expression and cell cycling. Hepatology. 1996; 24 (4): 137A.

11. M Ott, RJ Stockert, S Gagandeep, S. Gupta. Simultaneous modulation of viral receptor expression and cell cycling is necessary for maximizing retroviral gene transfer. Gene Therapy, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York. 1996; 233.

12. M Ott, S Gagandeep, S. Gupta. Modulation of retroviral receptor activity and cell cycling independently regulate retroviral gene transfer. Journal of Investigative Medicine. 1996; 44: 278A.

13. P Rajvanshi, D Liu, M Ott, S Gagandeep, S Gupta. Cell-ploidy based fractionation of hepatocyte subpopulations for highly efficient retroviral gene transfer. Hepatology. 1995; 20 (4): 219A.

14. P Rajvanshi, K Bhargava, S Gagandeep, C Palestro, S Gupta. 99m-Tc-Labelled human serum albumin microspheres are effective and degradable cell surrogates for analyzing safety of hepatocyte transplantation. Hepatology. 1995; 20 (4): 212A.

15. M Ott, Q Ma, S Gagandeep, LE Rogler, S Gupta. Interactions among transcription factors and their repressors differentially regulate HBV enhancer I and PreS1 promoter in hepatocytes, stem cells and fibroblasts. Hepatology. 1997; 22 (4): 270A.

16. S.Slehria, S Gagandeep, P Rajvanshi, R Sokhi, J Furgiuele, K Bhargava, C Palestro, S Gupta. Long-term repopulation with transplanted hepatocytes in cirrhotic F344 rats. Hepatology. 1998; 28(4): 358A.

17. S.Slehria, S Gagandeep, Q Ma, R Sokhi, L Guan, J Furgiuele, RA DePinho, S Gupta. C-myc antagonism with perturbation of G0/G1 transit leads to hepatocyte ablation and subacute liver failure. Hepatology. 1998; 28(4): 520A.

18. C Guha, B Vikram, S Gupta, A Sharma, A Alfieri, S Gagandeep, RP Sokhi, GR Gorla., KE Tanaka, J Roy Chowdhury. Hepatocyte transplantation repopulates the liver and increases survival after partial hepatectomy and whole liver irradiation in F344 rats. Gastroenterology. 1998; 114 (4): A1250

• 1993
  Treatment of metastatic carcinoma of the liver using the HSV1-TK suicide gene.
  René Descartes University, Paris. (Preceptor: Prof. D. Houssin)

• 1988
  Thyroid malignancies in the young.
  University of Bombay, India. (Preceptor: Prof. P.B. Desai)

• S Gagandeep, S Gupta. Liver Transplantation: ‘Principles of Medical Biology’. Ed. Bittar EE. Jaipress Inc., Greenwich, USA. 1996

• for the journal Gastroenterology (adhoc)

• May ’97
  The 97th Annual Meeting: American Gastroenterological Association, WashingtonDC.
  Loss of adenovirally transduced cells rather than transgene extinction is rate limiting in adenoviral hepatic gene therapy.

• Apr. ’97
  American Federation for Medical Research, Biomedicine ’97, Washington DC.
  Hepatocyte transplantation systems provide evidence for clearance of adenovirally transduced cells as against transgene extinction.

• Nov. ’96
  American Association for the Study of Liver Diseases (AASLD), Chicago.
  1. Arrest of hepatic oncogenesis and growth factor expansion by the c-myc antagonist MAD transcription factor. 2. Paclitaxel exhibits anti-tumor activity in hepatocellular carcinoma cell lines.

• May ’96
  American Federation for Clinical Research, Biomedicine ’96, Washington DC.
  Inhibition of C-MYC transactivation by MAD transcription Factor interrupts cycling in HCC.

• Nov. ’95
  Fourth International Conference on Gene Therapy for Cancer, San Diego.
  Prodrug activated gene therapy: Involvement of an immunological component in the “bystander effect”.

• Nov. ’94
  British Association of Surgical Oncology, London, Royal College of Surgeons.
  Suicide gene therapy: The “Bystander Effect” has a definite immunologic component.

• Nov. ’94
  UICC: XVI International Cancer Congress, New Delhi.
  Regression of established macroscopic liver metastases after in situ transduction of a suicide gene and an insight into the “bystander effect”.

• Sept. ’94
  European Conference of Gene Therapy for Cancer, London.
  Regression of established macroscopic liver metastases after in situ transduction of the HSV1-TK suicide gene.

• Jan. ’92
  V National Cancer Congress, (Madras). Carcinoma of the Stomach: A TMHosp Experience.

• Oct. ’91
  National Conference of the Indian Society of Gastroenterology, (Trivandrum)
  The technique and results of Whipple Pancreatoduodenectomy.

• Dec. ’91
  Association of Surgeons of India, (Hyderabad).
  Resection of pulmonary metastasis in colorectal carcinoma.

• Sept. ’91
  Indian Association of Surgical Oncology, (Baroda).
  Chylothorax following surgery for Carcinoma Oesophagus.

• Sept. ’91
  Indian Association of Surgical Oncology, (Baroda). Primary Melanomas of the Oesophagus.

Apr.’99
15th Annual Transplant Update Workshop. Talk on “The Organ Recovery Operation”. Nov. ’94
Chairman along with Drs. P. Stambrook : Gene Therapy for Cancer at the XVI International Cancer Congress (UICC) Oct. ’91
Annual Conference of the Royal College of Surgeons of Edinburgh in association withInternational College of Surgeons. Invited for the Laparoscopic Workshop, to demonstrate techniques for resection anastomosis for Ca Rectum using staplers.

• Residents Basic Science Lectures:
  • UIHC-Iowa: November 1998
  • MMC-Phoenix: 1999-2002
  • Also several lectures at Royal Liverpool University Hospital & Tata Memorial Hospital
• ATLS training: Have trained all levels of physicians from different specialties at a number of ATLS courses
• Resident training at all levels through out my medical career
• Operating Room Training: Trained Residents & Junior Fellows through various minor & major surgeries
• Teaching Rounds
• Lectures for nurses
• Transplantation awareness lectures to the community

• American Society of Transplantation
• American Association for the Advancement of Science
• American Medical Association

• 2002
  California State Medical License
  Active

• 1999
  Arizona State Medical License
  Inactive

• 1997
  Iowa State Medical License
  Inactive

• 1994
  UK (General Medical Council)
  Inactive

• 1985
  India (Maharashtra Medical Council)
  Active

Through College & Medical School

• Dramatics and Debating
• Sports: represented the University and the State in Squash and Table Tennis

Current Interests

• Tennis, Racquetball, Trekking, Canvas Painting & Music