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Faculty & Staff
Kasper S. Wang, M.D.

Kasper S. Wang, M.D.

Pediatric Surgeon
Associate Professor of Surgery (Clinical Scholar)
General Pediatric Surgery

Dr. Wang is a graduate of the Johns Hopkins University and the Johns Hopkins University School of Medicine. He completed eight years of general surgery training at Stanford University Hospital and subsequently two years of fellowship training in pediatric surgery at Children's Hospital Los Angeles. Dr. Wang balances a busy clinical practice with both clinical and basic research endeavors.

Dr. Wang's academic interest focuses on biliary atresia. Biliary atresia is a disease of infants where the bile ducts are damaged due to unclear causes. As a consequence of the damage, bile is unable to flow from the liver and progressive liver damage occurs. Biliary atresia is the most common indication for pediatric liver transplantation. Dr. Wang is the Principal Investigator for an NIH funded U01 grant for CHLA focusing on biliary atresia and other liver diseases of infants and children. The grant enables CHLA to participate in the Childhood Liver Disease Research and Education Network (ChiLDREN) which is a consortium of 15 of the top children's hospitals in the U.S. and Canada joined to studies rare but lethal pediatric liver diseases. To date, nearly 1500 patients with biliary atresia have been enrolled in number studies and clinical trials through ChiLDREN. Currently enrollment in a prospective randomized double blinded placebo controlled study on the efficacy of corticosteroids in the treatment of patients with biliary atresia after Kasai portoenterostomy is closed. Unblinding of data will occur in 2013 to be followed by publication of observations. In addition to involvement in ChiLDREN, Dr. Wang heads a research program focusing on the molecular events involved in biliary atresia. His research lab focuses on the signaling pathways regulating liver stem/progenitor cells during liver organogenesis and a variety of liver damage such as that incurred by biliary atresia.

Education

College: The Johns Hopkins University

Medical School: The Johns Hopkins University School of Medicine

Internship: Stanford University Hospital: General Surgery

Residency: Stanford University Hospital: Resident and Administrative Chief Resident in General Surgery

Fellowship: Children's Hospital Los Angeles: Pediatric Surgery

Expertise

Primary Specialty: General Pediatric Surgery

Secondary Specialty: Pediatric Surgery

Clinical Interests: Minimally invasive surgery of the chest and abdomen, hepatobiliary diseases of infants and children, solid tumors, esophageal disorders, biliary atresia, correction of pectus excavatum and pectus carinatum chest wall deformities.

Research

Research Interests: Signaling pathways regulating liver stem cells and progenitor cells during liver organogenesis and regeneration and cholestatic liver diseases.

Selected Publications:

  • Superina R, Magee JC, Brandt ML, Healey PJ, Tiao G, Ryckman F, Karrer FM, Iyer K, Fecteau A, West K, Burns RC, Flake A, Lee H, Lowell JA, Dillon P, Colombani P, Ricketts R, Li Y, Moore J, Wang KS and the Childhood Liver Disease Research and Education Network. The anatomic pattern of biliary atresia identified at time of Kasai hepatoportoenterostomy and early postoperative clearance of jaundice are significant predictors of transplant-free survival. Annals of Surgery. 254(4): 577-585, 2011. PubMed PMID 21869674.
  • Berg T, DeLanghe S, Al Alam D, Utley S, Estrada J, Wang KS. Beta-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. Journal of Surgical Research. 164: 276-285, 2010. PubMed PMID: 20381814; PubMed Central PMCID: PMC290482.
  • Galicia VA, He L, Dang H, Kanel G, Vendryes C, French B, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ,Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in PTENdeficient mice requires liver injury and is reversed by deletion of Akt2. Gastroenterology. 139(6):2170-82, 2010. PubMed PMID: 20837017.
  • Stamp L, Braxton D, Wu J, Akopian V, Hasegawa K, Chandrasoma P, Hawes S, McLean C, Petrovic L, Wang KS, Pera M. The GCTM-5 Epitope Associated With The Mucin-Like Glycoprotein FCGBP Marks Progenitor Cells In Tissues Of Endodermal Origin. Stem Cells July 3, 2012 Epub ahead of print. Pubmed PMID 22761039
  • Berg T, Lee L, Rountree CB, Estrada, J, Sala F, Choe A, Veltmaat J, DeLanghe S, Lee R, Tsukamoto H. Crooks G, Bellusci S, Wang KS. Fibroblast growth Factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 46(4): 1187-1197, 2007. PubMed PMID: 17668871.

Accomplishments

Certification: Surgery and Pediatric Surgery: American Board of Surgery

Medical Memberships: American Medical Student Association; Association for Academic Surgery; Los Angeles Surgical Society; American Pediatric Surgical Association; American Association for the Study of Liver Diseases; Pacific Association of Pediatric Surgery; Society of University Surgeons; Society of Asian American Surgeons; Fellow of the American College of Surgeons; Fellow of the American Academy of Pediatrics; Committee on Fetus and Newborn Liaison, Section on Surgery Representative; Association for Academic Surgery; ChiLDREN Consortium: Steering Committee Member, Surgery Committee Chairman, START protocol Working Group Co- chairman, Pilot Projects Review Committee Member; American Association for the Study of Liver Diseases: "Clinical Liver Transplantation and Liver Surgery: Living Donor & Split Liver Transplantation, Hepatobiliary Surgery" Review Committee Member

 

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