Children's Hospital Los Angeles is one of 14 children’s hospitals across the nation that is a designated site of the National Institutes of Health (NIH) funded Childhood Liver Disease Research and Education Network (ChiLDREN). ChiLDREN represents the continuation of two previous NIH-funded consortia, the Biliary Atresia Research Consortium (BARC) and the Cholestatic Liver Consortium (CLiC).
The goals of ChiLDREN are:
To study rare pediatric liver diseases such as biliary atresia, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis, Alagille syndrome, bile acid synthesis defects, and mitochondrial hepatopathies.
To provide a resource for education on these rare liver conditions for families, pediatricians and gastroenterologists.
We are currently enrolling infants and children for the following studies:
A Prospective Database of Infants with Cholestasis (PROBE): This study is open to infants less than 180 days of age, diagnosed with cholestasis (blockage of bile flow).
A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterosotomy in Infants With Biliary Atresia (START): This study is open to infants less than 180 days of age, diagnosed with biliary atresia who are also enrolled in a Prospective Database of Infants with Cholestasis (PROBE).
Biliary Atresia Study in Infants and Children (BASIC): This study is open to infants and children over 1 year of age, diagnosed with biliary atresia.
Longitudinal Study of Genetic Casues of Intrahepatic Cholestasis (LOGIC): This study is open to children, adolescents and young adults, diagnosed with one of four types of cholestasis (blockage of bile flow): Alagille syndrome, alpha-1 antitrypsin deficiency, progressive familial intrahepatic cholestasis and bile acid synthesis defects.
Longitudinal Study of Mitochondrial Hepatopathies (MITOHEP): This study is open to infants and children with diagnosed or suspected mitochondrial hepatopathy.