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ChilDREN Liver Research Center

Children's Hospital Los Angeles is one of 14 children’s hospitals across the nation that is a designated site of the National Institutes of Health (NIH) funded Childhood Liver Disease Research and Education Network (ChiLDREN). ChiLDREN represents the continuation of two previous NIH-funded consortia, the Biliary Atresia Research Consortium (BARC) and the Cholestatic Liver Consortium (CLiC).

Center Goals

The goals of ChiLDREN are:

  • To study rare pediatric liver diseases such as biliary atresia, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis, Alagille syndrome, bile acid synthesis defects, and mitochondrial hepatopathies.
  • To provide a resource for education on these rare liver conditions for families, pediatricians and gastroenterologists.
Current Studies

We are currently enrolling infants and children for the following studies:

  • A Prospective Database of Infants with Cholestasis (PROBE): This study is open to infants less than 180 days of age, diagnosed with cholestasis (blockage of bile flow).
  • A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterosotomy in Infants With Biliary Atresia (START): This study is open to infants less than 180 days of age, diagnosed with biliary atresia who are also enrolled in a Prospective Database of Infants with Cholestasis (PROBE).
  • Biliary Atresia Study in Infants and Children (BASIC): This study is open to infants and children over 1 year of age, diagnosed with biliary atresia.
  • Longitudinal Study of Genetic Casues of Intrahepatic Cholestasis (LOGIC): This study is open to children, adolescents and young adults, diagnosed with one of four types of cholestasis (blockage of bile flow): Alagille syndrome, alpha-1 antitrypsin deficiency, progressive familial intrahepatic cholestasis and bile acid synthesis defects.
  • Longitudinal Study of Mitochondrial Hepatopathies (MITOHEP): This study is open to infants and children with diagnosed or suspected mitochondrial hepatopathy.
Our Team

The ChiLDREN Liver Center is headed by:

Kasper S. Wang, MD, FACS, FAAP
Principal Investigator
Dr. Wang runs a research program that studys the role of liver stem cells in biliary atresia.

Sonia Michail, MD
Co-Investigator
Dr. Michail is a board-certified pediatric gastroenterologist whose primary specialty is pediatric gastroenterology.

Daniel Thomas, MD
Co-Investigator
Dr. Thomas is the division head of Gastroenterology and Nutrition and professor of Clinical Pediatrics, Keck School of Medicine of USC.

Cat Goodhue, CPNP
Research Coordinator
Ms. Goodhue is a board-certified pediatric nurse practitioner with experience in conducting clinical trials.

 

 

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