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William W. Tseng, MDWilliam W. Tseng, MD

Assistant Professor of Surgery
University of Southern California, Keck School of Medicine


USC Surgical Oncology
1510 San Pablo St., #412
Los Angeles, CA 90033

Phone: (323) 865-1535
Fax: (323) 865-0164


  • Keck Hospital of USC
  • Huntington Memorial Hospital
  • Los Angeles County + USC Medical Center
  • Hoag Memorial Hospital Presbyterian


William W Tseng, MD is Assistant Professor of Surgery at the Keck School of Medicine at USC. He obtained his undergraduate and medical degrees from Northwestern University, under the Honors Program in Medical Education. He did residency training in General Surgery at the University of California at San Francisco and then completed subspecialty fellowship training in Surgical Oncology at the University of Texas M.D. Anderson Cancer Center.

Dr. Tseng‘s clinical focus and expertise is in soft tissue sarcoma and melanoma. He has published extensively and won several awards for work done in both of these disease areas. Dr. Tseng’s research interest is in tumor immunology and immunotherapy. He completed dedicated research fellowships in immunology at Stanford University and M.D. Anderson.

Dr. Tseng is also recognized for his specialized clinical and research expertise in well differentiated / dedifferentiated liposarcoma. His previous work was the first to identify an immune response in liposarcoma and he is frequently invited to give lectures on this topic. His current research strives to develop immunotherapy as a treatment option for patients with this disease.


  • Surgical Oncology
  • Sarcoma
  • Melanoma

Board Certification

  • Surgery


  • English
  • Mandarin, Taiwanese


College or University

  • Northwestern University, Evanston, Illinois, Bachelor of Arts (Biology)

Medical School

  • Northwestern University, Feinberg School of Medicine, Chicago, Illinois, Doctorate of Medicine


  • University of California at San Francisco, (General Surgery), San Francisco, California

Fellowship - Clinical

  • The University of Texas M.D. Anderson Cancer Center, (Surgical Oncology), Houston, Texas

Fellowship - Research

  • Stanford University School of Medicine, (Tumor Immunology), Palo Alto, California
  • The University of Texas M.D. Anderson Cancer Center, (Liposarcoma Immunology), Houston, Texas

Professional Society Memberships

  • American College of Surgeons, 2004-current
  • Society of Surgical Oncology, 2011-current
  • Connective Tissue Oncology Society, 2013-current
  • American Society of Clinical Oncology, 2014–current

Honors and Awards

  • Science Education Award, American Association for Cancer Research, 2001
  • Resident’s Research Award, Society for Surgery of the Alimentary Tract, 2002
  • Julius Conn Award, Northwestern University Feinberg School of Medicine, Department of Surgery, 2003
  • Research Award (NCI R13), 4th International Symposium on Cancer Metastasis and the Lymphovascular System, 2011
  • Merit Award, American Society of Clinical Oncology, Conquer Cancer Foundation, 2014

Select Publications - Sarcoma

  • Tseng WW, Eichler CM, Warren RS, Nakakura EK. Complete and Safe Resection of Challenging Retroperitoneal Tumors: Anticipation of Multi-organ and Major Vascular Resection and Use of Adjunct Procedures. World J Surg Oncol 2011 Nov 4; 4(9):143. PMID: 22054416
  • Tseng WW, Demicco EG, Lazar AJ, Lev DC, Pollock RE. Lymphocyte Composition and Distribution in Inflammatory, Well-Differentiated Retroperitoneal Liposarcoma: Clues to a Potential Adaptive Immune Response and Therapeutic Implications. Am J Surg Pathol 2012 Jun; 36(6):941-4. PMID: 22446945
  • Tseng WW, Somaiah N, Lazar AJ, Lev DC, Pollock RE. Novel Systemic Therapies in Advanced Liposarcoma: A Review of Recent Clinical Trial Results. Cancers 2013 May 10; 5(2):529-549. PMID: 24216990
  • Tseng WW, Madewell JE, Wei W, Somaiah N, Lazar AJ, Ghadimi MP, Hoffman AL, Pisters PW, Lev DC, Pollock RE. Locoregional Disease Patterns in Well Differentiated and Dedifferentiated Retroperitoneal Liposarcoma: Implications for the Extent of Resection? Ann Surg Oncol 2014 Jul; 21(7): 2136-43. PMID: 24705628
  • Tseng WW, Somaiah N, Engleman EG. Potential for Immunotherapy in Soft Tissue Sarcoma. Hum Vaccin Immunother 2014;10(11):3117-24. PMID:25625925
  • Tseng WW, Amini B, Madewell JE. Follow-up of the soft tissue sarcoma patient. J Surg Oncol 2015 Apr;111(5):641-5. PMID:25322963
  • Amini B, Jessop AC, Ganeshan DM, Tseng WW, Madewell JE. Contemporary imaging of soft tissue sarcomas. J Surg Oncol 2015 Apr;111(5):496-503. PMID:25348367
  • Ikoma N, Torres KE, Somaiah N, Hunt KK, Cormier JN, Tseng W, Lev D, Pollock R, Wang WL, Feig B. Accuracy of Preoperative Percutaneous Biopsy for the Diagnosis of Retroperitoneal Liposarcoma Subtypes. Ann Surg Oncol 2015 Apr;22(4):1068-72. PMID:25354575
  • Tseng WW, Malu S, Zhang M, Chen J, Sim GC, Wei W, Ingram D, Somaiah N, Lev DC, Pollock RE, Lizee G, Radvanyi L, Hwu P. Analysis of the intratumoral adaptive immune response in well differentiated and dedifferentiated retroperitoneal liposarcoma. Sarcoma 2015: 547460. PMID:25705114
  • Olimpiadi Y, Song S, Hu JS, Matcuk GR, Chopra S, Eisenberg BL, Sener SF, Tseng WW. Contemporary Management of Retroperitoneal Soft Tissue Sarcomas. Curr Oncol Rep 2015 Aug;17(8): 39. PMID: 26092408
  • Tseng WW, Zhou S, To CA, Thall PF, Lazar AJF, Pollock RE, Lin PP, Cormier JN, Feig BW, Hunt K, Ballo MT, Patel S, Pisters PWT. Phase I adaptive dose-finding study of neoadjuvant gemcitabine combined with radiation therapy for patients with high-risk extremity and trunk soft tissue sarcoma. Cancer 2015 Oct 15;121(20):3659-67. PMID: 26177983
  • Khoury M, Sim GC, Harao M, Radvanyi L, Amini B, Benjamin RS, Pisters PWT, Pollock RE, Tseng WW. Multicystic Dedifferentiated Retroperitoneal Liposarcoma: Tumor Cyst Fluid Analysis and Implications for Management. BMJ Case Rep 2015 Jul 8;2015. PMID: 26156843
  • Byerly S, Chopra S, Nassif NA, Chen P, Sener SF, Eisenberg BL, Tseng WW. The Role of Margins in Extremity Soft Tissue Sarcoma. J Surg Oncol 2016 Mar;113(3):333-8. PMID: 26662660
  • Tseng WW, Chopra S, Engleman EG, Pollock RE. Hypothesis: The Intratumoral Immune Response against a Cancer Progenitor Cell Impacts the Development of Well-Differentiated versus Dedifferentiated Disease in Liposarcoma. Front Oncol 2016 Jun 10; 6:134. PMID: 27376027
  • Tseng WW, Pollock RE, Gronchi A. The Trans-Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG): "Red wine or white?" Ann Surg Oncol 2016 Dec; 23(13):4418-4420. PMID: 27613555
  • Nassif NA, Tseng W, Borges C, Chen P, Eisenberg B. Recent advances in the management of liposarcoma F1000Res. 2016 Dec 22;5:2907. PMID: 28105325
  • Tseng WW, Gronchi A. Surgery for recurrence in retroperitoneal leiomyosarcoma: Is it all about selection? J Surg Oncol. 2017 Sep;116(3):267-268. PMID: 28672078
  • In GK, Hu JS, Tseng WW. Treatment of soft tissue sarcoma: latest evidence and clinical considerations. Ther Adv Med Oncol. 2017 Aug;9(8):533-550. PMID: 28794805
  • Livingston JA, Bugano D, Barbo A, Lin H, Madewell JE, Wang WL, Lazar AJ, Tseng WW, Roland CL, Feig BW, Pollock R, Conley AP, Benjamin RS, Patel S, Somaiah N. Role of chemotherapy in dedifferentiated liposarcoma of the retroperitoneum: defining the benefit and challenges of the standard Sci Rep 2017 Sep 19;7(1):11836. PMID: 28928422
  • Tseng WW, Seo HJ, Pollock RE, Gronchi A. Historical Perspectives and Future Directions in the Surgical Management of Retroperitoneal Sarcoma J Surg Oncol (in press)
  • Tseng WW, Pollock RE, Gronchi A. Retroperitoneal Sarcomas: Big tumors that Involve More than Just “Getting It Out”. J Surg Oncol (in press)

Select Publications - Melanoma

  • Tseng W, Doyle J, Maguiness S, Horvai A, Kashani-Sabet M, Leong S. Giant Cutaneous Melanomas: Evidence for Primary Tumor-Induced Metastatic Site Dormancy? BMJ Case Reports 2009; Epub 2009 Oct 5; doi:10.1136/bcr.07.2009.2073. PMID: 21977058
  • Tseng WW, Fadaki N, Leong SP. Metastatic Tumor Dormancy in Cutaneous Melanoma: Does Surgery Induce Escape? Cancers 2011 Feb 21; 3(1):730-746. PMID: 24212638
  • Tseng WW, Leong SP. Long-term survivors after Immunotherapy for Metastatic Melanoma. Immunol Lett 2011 Sept 30; 139(1-2):117-8. PMID: 21596063
  • Ruschulte H, Shi S, Tseng WW, Kolodzie K, Crawford PC, Schneider D, Kashani-Sabet M, Minor D, Apfel C, Leong SPL. Anesthesia management of patients undergoing hyperthermic isolated limb perfusion with melphalan for melanoma treatment: an analysis of 17 cases. BMC Anesthesiology 2013 July 17; 13(1): 15.  PMID: 23865420
  • Leong SP, Tseng WW. Micrometastastic Cancer Cells in Lymph Nodes, Bone Marrow and Blood: Clinical Significance and Biologic Implications. CA Cancer J Clin 2014 May-Jun; 64(3): 195-206. PMID:24500995

Research Grants

  • "Immune Profiling in Well Differentiated / Dedifferentiated Liposarcoma," Sarcoma Alliance for Research through Collaboration (SARC), Developmental Research Program, Role: Principal Investigator, 2016-current

Curriculum Vitae (full list of publications, abstract presentations) - PDF file, 61KB









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Upper G.I. and General Surgery

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