Keck School of Medicine of USC - University of Southern California Keck School of Medicine of USC University of Southern California
Department of Surgery
Department links
Home Physicians Locations Education Society of Graduate Surgeons Contact Us Divisions and Institutes
Vascular Surgery
Divisional navigation image map
Areas of Expertise Clinical Programs Clinical Research Vascular Nursing Support Services
Patient Guide Web Links Calendar of Events Contact Us

Clinical Research

Currently, the Division of Vascular Surgery and Endovascular Therapy, in conjunction with the Keck School of Medicine of USC, has the following Research Studies for which it is actively screening and enrolling patients.

Research Studies

I. Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial CREST-2

Sponsor:  National Institute of Neurological Disorders and Stroke of the National Institutes of Health
Facility: Keck Medical Center of USC and LAC+USC Medical Center
Principal Investigator: Fred A Weaver, MD

CREST-2 is a national multicenter stroke prevention study comparing intensive medical management alone to intensive medical management used in combination with a procedure to remove plaque buildup from the carotid artery in the neck, in patients without stroke or stroke warning signs. Study participants will continue to see their primary physicians during follow-up.

We are looking to enroll patients who:

  • Are at least 35 years old
  • Have narrowing of at least one carotid artery
  • Not have other serious medical conditions<

Persons requesting additional information or are interested in potential participation are encouraged to contact Sylvia Ramos, CCRP, sramos@usc.edu, 323-442-5763.

II. Autologous Bone Marrow Aspirate Concentrate For The Treatment Of Critical Limb Ischemia Due To Peripheral Arterial Occlusive Disease

Sponsor: Harvest Technologies
Facility: Keck Hospital of USC

The primary objective of this clinical study is to evaluate the safety and effectiveness of a concentrate of nucleated cells and other cellular components from bone marrow aspirate produced with the Harvest Bone Marrow Aspirate Concentrate System for treating lower limbs diagnosed with critical ischemia due to peripheral arterial occlusive disease. Enrolled subjects will be randomized to the investigational treatment or placebo. Subjects will receive extensive follow-up for 24 months.

We are looking to enroll patients who:

  • Are 18 years of age or older
  • Have diffuse foot ischemia with focal tissue loss and/or gangrene

Persons requesting additional information or are interested in potential participation are encouraged
to contact Karen Manrique, karen.manrique@med.usc.edu, 323-442-8176.

III. Maturation of Arteriovenous Fistulas in the Elderly Hemodialysis Population

Sponsor: Funded by a Keck School of Medicine Medical Faculty Women’s Association Grant
Facility: Keck Hospital of USC and LAC+USC Medical Center

The purpose of this study is to evaluate factors which may influence maturation of arteriovenous fistulas in the elderly hemodialysis population. This is a prospective, observational study. Enrolled subjects will undergo standard evaluation and treatment for creation of an arteriovenous fistula. Subjects will be followed until the fistula is ready for use for hemodialysis, or is determined to be a failure to mature.

We are looking to enroll patients who are:

  • 60 years of age or greater
  • Are anticipated to start hemodialysis in one year or less
  • Are candidates for creation of an arteriovenous fistula for hemodialysis

Persons requesting additional information or are interested in potential participation are encouraged
to contact Karen Manrique, karen.manrique@med.usc.edu, 323-442-8176.

IV. Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial

Sponsor: National Institutes of Health
Facility: Keck Hospital of USC
Principal Investigator: Fred A Weaver, MD

The purpose of the study is to determine whether doxycycline administration can decrease the rate of growth of small abdominal aortic aneurysms. Participants will be randomized to doxycycline or placebo. Participants will be followed for two years with imaging studies and lab tests for various biomarkers as well as quality of life questionnaires.

We are looking to enroll patients who:

  • Have an abdominal aortic aneurysm with a diameter of at least 35 mm
  • Have not had a previous repair of an abdominal aortic aneurysm

Persons requesting additional information or are interested in potential participation are encouraged
to contact Karen Manrique, karen.manrique@med.usc.edu, 323-442-8176.

 

Recent Clinical Research Publications

In the Division of Vascular Surgery at USC, we are continually examining our clinical outcomes and looking for ways that our experience can contribute to medical knowledge and advancement of the care of patients with vascular disease. Some of our recent publications are:

 

 

Share this page:
 

USC Vascular Logo

Address

USC Vascular Surgery
1520 San Pablo St.
Suite 4300
Los Angeles, CA 90033-5330

E-mail: vascular@med.usc.edu
Phone: (323) 865-1544

Click map to go to directions

 
Copyright © Vascular Surgery
University of Southern California Department of Surgery
Keck School of Medicine of USC
1520 San Pablo St., Suite 4300, Los Angeles, CA 90033-5330
Email: vascular@med.usc.edu
Home Faculty and Staff Hospitals and Offices Education and Fellowships Make an Appointment